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Under-Dominance Constrains the Evolution of Negative Autoregulation in Diploids

Figure 3

Response times and allele expression.

This figure shows quantitative results for the contributions of different alleles to expression and to response time. (a) Expression level of the resident allele (black line) and the mutant allele (red line) in the heterozygote relative to the resident allele in the homozygote. As binding strength increases the resident allele is over-expressed. (b) Response times for individual alleles (time to return to of the equilibrium expression level) in the heterozygote. The response time of the resident allele (black line) and the mutant allele (red line) in the heterozygote are shown relative to the response time of the resident allele in the homozygote. The resident allele in the heterozygote shows an increased response time with increasing binding strength. Mutant alleles in these graphs have dissociation constant , and the optimal binding strength in these graphs is , corresponding to a background transcription rate .

doi: https://doi.org/10.1371/journal.pcbi.1002992.g003