A Multi-scale Analysis of Influenza A Virus Fitness Trade-offs due to Temperature-dependent Virus Persistence

doi:10.1371/journal.pcbi.1002989

A Multi-scale Analysis of Influenza A Virus Fitness Trade-offs due to Temperature-dependent Virus Persistence

Figure 6

Relative Fitness for the 12 influenza strains.

A) direct transmission (equation 19) and B) environmental transmission (equation 20) scenarios. We plot fitness for the three different link functions, , between within-host virus load and transmission/shedding described in the model section, i.e. , and given by equations (12), (15) and (16). Strains are sorted according to within-host fitness, with H8N4 having the best within-host fitness (i.e. lowest value of , see Table 4). We arbitrarily chose H1N1 as the reference strain, which therefore has a relative fitness of 1.

doi: https://doi.org/10.1371/journal.pcbi.1002989.g006