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A Multi-scale Analysis of Influenza A Virus Fitness Trade-offs due to Temperature-dependent Virus Persistence

Figure 5

Best fit of within-host model to fecal virus load from influenza infections of mallards (Anas Platyrhynchos).

The limit of detection for the virus load was ( = 50% Egg Infectious Doses) and is indicated by the dashed horizontal line. See [69] for more details on the experiments and data. Fitting was done using a least squares approach for the logarithm of the virus load, corresponding to the assumption of log-normally distributed errors [89]. For data at the limit of detection (i.e. left-censored data), differences between model and data were accounted for if the model was above the data point, but not if the model took on any value below the limit of detection [75].

doi: https://doi.org/10.1371/journal.pcbi.1002989.g005