A Multi-scale Analysis of Influenza A Virus Fitness Trade-offs due to Temperature-dependent Virus Persistence
Figure 2
Flow diagram for the between-host model.
,
and
are the variables describing susceptible hosts, infected hosts, and pathogen (i.e. virus) in the environment. Transmission can occur directly between uninfected and infected hosts at rate
and through contact of uninfected hosts with virus in the environment at rate
. Infected hosts shed virus into the environment at rate
, and recover (and are assumed to become immune to re-infection) at rate
. Virus in the environment decays at rate
. Note that the parameters
,
and
, i.e. the rate of transmission between hosts, the rate of shedding and the rate of recovery all depend on the time since infection. Solid lines indicate physical flows, dashed lines indicate interactions.