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A Circadian Clock-Regulated Toggle Switch Explains AtGRP7 and AtGRP8 Oscillations in Arabidopsis thaliana

Figure 4

The slave oscillator may represent a driven bistable toggle switch.

A) The –-bifurcation diagram of the slave oscillator decoupled from the core oscillator consists of four main regions: two monostable areas (blue and green), a bistable area (red), and an area where autonomous oscillations are possible (yellow). Dashed lines indicate the directions in parameter space used for the one parameter bifurcation diagrams in Figure S6. The intersection of these lines marks the optimal parameter set from Table 1. The black curve is discussed in detail in the main text. B) Modification of the splicing coefficients and , responsible for the reciprocal cross-regulation, affects the slope of the boundaries between the bistable and the monostable regions (black: original boundaries, color: modified boundaries). C) & D) Color-coded fixed point concentrations and of AtGRP7 and AtGRP8 protein in the monostable areas. Straight lines with black and white dots are explained in the main text.

doi: https://doi.org/10.1371/journal.pcbi.1002986.g004