Processing of Multi-dimensional Sensorimotor Information in the Spinal and Cerebellar Neuronal Circuitry: A New Hypothesis
Figure 2
Piecewise-linear (PL) approximations in the cerebellar neuronal network.
(A) Using the excitatory input directly from PF and the inhibitory pathway through molecular layer interneurons, the PC can construct a PL approximation of arbitrary non-linear functions of the input reaching the GrCs. (top) Two PFs innervate the PC directly (3 & 4), while the other two innervate a stellate interneuron (1 & 2). (middle) The four GrCs have slightly different thresholds and varying MF efficacy leading to varying activity slopes. (bottom) The PC modulates its output using the input coming from the GrCs according to Eq. (1). The path through the inhibitory molecular layer interneurons allows the weight and thus the slope of the curve to be negative. Each GrC threshold corresponds to one knot in the PL PC output. (B) The distribution of GrC thresholds over the input range determines how well the PC can approximate the non-linear regions of the approximated function. (top) Several receptive fields can contribute to measure a single intrinsic dimension. In this case, the skin stretch can be used to deduce the joint angle. (middle) The different receptive fields allow the GrC thresholds to be spread over a larger input range than that using only a varying degree of Golgi cell tonic inhibition. (bottom) Sum of activity of all GrCs activated from the three receptive fields. As the population GrC activity rises over the entire input range, their output could be used to approximate non-linearities over the entire input range. (C) A naïve approach to enable the PC output to approximate functions of two-dimensions. In this example, afferent information from skin stretch and Ib afferents are added separately in the PC, generating an approximated surface. At each point in the input space, the PC output is calculated by adding the contribution from GrCs innervated by the two separate afferent types.