Computational Biomarker Pipeline from Discovery to Clinical Implementation: Plasma Proteomic Biomarkers for Cardiac Transplantation
Figure 3
Linear Discriminant Analysis classifier score (Classifier score) when patients transitioned between non-rejection (NR) and acute rejection (AR) episodes. The first consecutive AR time points were averaged (AR, pink solid point) from 7 AR patients. Non-rejection samples from the same patients, before and after AR (“NR before AR” and “NR after AR”) were averaged (pink solid triangle). The average time trend for these samples is represented with a pink solid line. A control curve (dashed green line) was constructed from 9 NR patients matched to AR patients by available time points (green solid triangle). Vertical lines represent standard errors. The asterisk (*) means that the two-sided t-test p value<0.001.