Computational Biomarker Pipeline from Discovery to Clinical Implementation: Plasma Proteomic Biomarkers for Cardiac Transplantation
Figure 1
Proteomic computational pipeline synopsis.
The 3-stage computational pipeline enables an initial untargeted exploration of the plasma proteome resulting in a list of potential biomarkers, followed by the validation of a set of candidate biomarkers that emphasizes the combination of candidate protein biomarkers into a classifier score with clinical utility. The bottom panel outlines the main steps of the computational pipeline that provide a systematic process from discovery to validation to clinical implementation of plasma protein biomarkers.