Functional Knowledge Transfer for High-accuracy Prediction of Under-studied Biological Processes
Figure 1
Functional knowledge of biological processes is far from uniform, even among closely related organisms.
Each node represents the number of experimentally annotated biological processes in an organism. Each edge value corresponds to the number of experimentally annotated processes in the source organism that lack any experimental annotations in the target organism. Thus, the directed edges between nodes indicate the direction of potential annotation transfer between organisms. For example, 3,245 processes with annotations in mouse have no experimentally annotated genes in rat.