Comparative RNA-seq Analysis in the Unsequenced Axolotl: The Oncogene Burst Highlights Early Gene Expression in the Blastema
Figure 5
Enrichment of oncogenes during the early time points.
All upregulated DE genes at each time point (when compared to the zero hour control) were interrogated for being oncogenes by their presence in the Memorial Sloan Kettering Cancer Center Oncogene set (http://cbio.mskcc.org/CancerGenes/Select.action) and then performing a Fisher's exact test to assess significance. The enrichment of oncogenes during the first day is highly statistically significant (P-value<10−5). Late in the time course, oncogenes are not significantly enriched in the upregulated DE gene sets.