Comparative RNA-seq Analysis in the Unsequenced Axolotl: The Oncogene Burst Highlights Early Gene Expression in the Blastema
Figure 3
Two-way clustering of all differentially expressed (DE, FDR<0.05) transcription factors (TFs).
Differential expression is relative to the zero hour control. Upper right: an early upregulated cluster of TFs dominated by oncogenes (ATF3, KLF4, KLF2, JUN3, EGR1, NR4A2, and FOS are all oncogenes). Oncogenes are highlighted with red text. Lower right: a cluster of TFs upregulated later in the time course including genes involved in limb development such as HOXD10 and HOXD11 (highlighted in blue text). Clustering and viewing was done with Mev 4.8.1 The distance measure used was the Pearson uncentered correlation with average linkage.