Dual Coordination of Post Translational Modifications in Human Protein Networks
Figure 4
PTMi spot containing proteins.
(A) Breakdown of the PTMs present in each of the 405 PTMi spots identified here. (B) Examples of single phospho-PTMi spot containing proteins with histograms of the local PTM density across the protein sequence. Colour codes beneath each density histogram represent the number of distinct PTMs (red scale) and the local STKY density (yellow∶blue scale, see legend [is in C]). (C) Multi-signal PTMi spot proteins. Examples of proteins annotated either as canonical PTMi spot containing protein, a protein that integrates both ubiquitin and multiple phosphorylations in a PTMi spot (putative degron), or to one of five key regulatory cellular modules. Representative examples of PTM density distributions of a protein in each sub-group is linked to the panel, a full list of PTMi spot containing proteins is found in Dataset S4.