Dual Coordination of Post Translational Modifications in Human Protein Networks
Figure 2
Signal integration on highly modified protein complexes.
(A) Percentage of total modifications across each specific group of complexes in comparison to all complexes in the dataset and all of the enriched complexes combined (Selected Complexes). Box plot represents the total number of modifications present across all complexes for each enriched group. (B) Schematic representations of potential PTM integration. Putative signal integration through distinct singly-modified subunits (i) is compared to more complex combinatorial signaling through multiply-modified subunits (ii). (C) Enrichment analysis for each subgroup of nodes. Each square represents the Z-score for an increase or decrease in signal compared to random samples from the entire complex dataset. * Represents Z-scores >35, not reflected by the colour code of the heatmap.