Dual Coordination of Post Translational Modifications in Human Protein Networks
Figure 1
Selectivity of post-translational modification on human protein complexes.
Median modification level of protein complexes plotted against total number of modifications for each PTM, with each data point representing a unique complex for (A) acetylation, (B) tyrosine phosphorylation, (C) ubiquitination and (D) serine/threonine phosphorylation. Data points may overlay preventing visualisation of each unique complex. The density data from 100 random datasets is overlaid on each plot with graded colours representing percentages of total randomized data. Complexes that are highly unlikely to be generated through random dataset generation are selected at confidence cut-offs of 99% for Ac, pY and Ub and 95% for pS/T and highlighted in red. (E) Overlap analysis for selected, highly modified complexes from 1A–D. (F) GO analysis highlighting coordinated differential molecular function control by each group of complexes selected in the above analysis. Ac & Ub represents the 57 complexes that are enriched for both these PTMs, ≥3PTMs represents the 39 complexes enriched in at least 3 PTMs.