Chapter 15: Disease Gene Prioritization
Figure 1
Overview of gene prioritization data flow.
In order to prioritize disease-gene candidates various pieces of information about the disease and the candidate genetic interval are collected (green layer). These describe the biological relationships and concepts (blue layer) relating the disease to the possible causal genes. Note, the blue layer (representing the biological meaning) should ideally be blind to the content green layer (information collection); i.e. any resource that describes the needed concepts may be used by a gene prioritization method.