Binding of Nucleoid-Associated Protein Fis to DNA Is Regulated by DNA Breathing Dynamics
Figure 4
Fis in vivo binding sites vs. randomly selected E. coli genomic sequences.
(A) Cumulative density functions of subsequences with most significant correlation with COP. The Fis binding sites dataset is shown as a red curve while the random sequences dataset is depicted as a blue curve. The x-axis is the Pearson correlation coefficient while the y-axis is the proportion of subsequences with a maximum correlation with the COP profile worst or equal to the corresponding x value. (B) Receiver-operating curves base on our SVM model as well as models built with CRoSSeD and BioBayesNet. The x-axis depicts the false positive rate while the y-axis depicts true positive predictions. The blue curve corresponds to the results from our SVM classifier, the red curve to ones from the CRoSSeD model, and the green curve to ones from the BioBayesNet model.