The Underlying Molecular and Network Level Mechanisms in the Evolution of Robustness in Gene Regulatory Networks
Figure 7
Network-architecture level mechanisms.
Correlation between the “other contributions” portion of the change in robustness (Fig. 5B) and the average network rewiring as a function of URR (L) and specificity gap (γ). Rewiring, Φ, was computed between individuals at generation 2000 and their respective founders (see Materials and Methods). These values were corrected for the effects of changing connectivity by calculating Φ between two randomly chosen stable individuals, both with the same average connectivity values observed for the individuals at the end of the simulations. The correlation shows that Φ explains for the most part the “other contributions” component of robustness. The amount of rewiring depends primarily on L and to a lesser extent on γ. Error bars are the standard error of the mean over 100 independent simulations.