The Underlying Molecular and Network Level Mechanisms in the Evolution of Robustness in Gene Regulatory Networks
Figure 6
Local-sequence level mechanisms.
(A) Resistance to creation of TFBSs within TFBS-free regions, measured as the frequency of silent mutation events (Fig. 4) normalized to the fraction of TFBS-free region in the genome. (B) TFBS conservation or degree of resilience to deletion of TFBSs, measured as the average probability that a TFBS will remain a TFBS following a point mutation. Error bars are computed as the standard error of the mean over 100 independent simulations.