Evolutionary Optimization of Protein Folding
Figure 2
Change in length and foldability during evolution: a) Size Modified Contact Order (SMCO) versus approximative F domain age in billion of years (Gya).
Each data point represents an SMCO average of domain belonging to the same F. Triangles show SMCO averages for domains belonging to the same F and experimentally known to be ultra-fast folders [27]. b) Average amino-acid chain length for domains belonging to the same F versus F domain age in Gya. The solid line shows a LOESS polynomial regression, and the grey shade the 95% confidence interval.