ADEMA: An Algorithm to Determine Expected Metabolite Level Alterations Using Mutual Information
Figure 8
Expected level changes found using ADEMA for metabolites on DNL Pathway.
Coloring scheme is the same as in Figure 7. Resulting expected metabolite changes are computed using ADEMA, for the CF mice w.r.t. WT mice (3-week-old mice). We see that Palmitic Acid and Stearic are decreased, as suggested by the flux measurement and ELOVL6 levels. The increases in Dodecanoic Acid and Tetradecanoic Acid can be explained by a downstream effect of Stearic and Palmitic Acid that lead to the accumulation of these two metabolites as they are no longer consumed.