ADEMA: An Algorithm to Determine Expected Metabolite Level Alterations Using Mutual Information
Figure 7
Results of significance testing for individual metabolites on DNL Pathway.
Dark grey-colored metabolite represents significant increase for a metabolite in CF, compared to WT (3-week-old mice). Grey represents “no significant change”, dark grey represents “significant increase”, and light grey represents “significant decrease”. Significance tests are done using student's t test per each metabolite independently. The results show that the path Decanoic Acid to Stearic shows no significant change other than an increase in Dodecanoic Acid even though (1) the flux is shown to be decreased on this path, and (2) ELOVL6 expression level is lower.