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ADEMA: An Algorithm to Determine Expected Metabolite Level Alterations Using Mutual Information

Figure 4

Illustration of combining expectations found by each EFM.

In this illustration, there are 8 metabolites that are analyzed. We have 6 different subsets of metabolites found using EFMs. For each one of them, expected levels for WT (right) and CF (left) are found as explained in Figure 3. Individual expected levels are weighted using equation 14 to obtain a WT-specific and a CF-specific level for each metabolite.

Figure 4

doi: https://doi.org/10.1371/journal.pcbi.1002859.g004