PERT: A Method for Expression Deconvolution of Human Blood Samples from Varied Microenvironmental and Developmental Conditions
Figure 5
PERT recovers compositions of culture-derived lineage-depleted (Lin-) human blood cells.
(A) Schematic of experiment setup. (B) Model predicted cell proportions of 11 blood cell lineages (defined in Figure 4) in day-4 Lin- human blood cell samples. (C) Flow cytometry assigned averaged cell proportions (N = 3) in the day-4 Lin- human blood cell samples shown in (B). (D) R2 calculated from the Pearson's correlation coefficients between the model predicted cell proportions and the ones assigned by flow cytometry. (E) Averaged absolute differences of model predicted cell proportions. Error bars show standard deviations of the absolute differences of the 11 blood cell lineages. (F) The Bayesian information criterion (BIC) calculated from the parameters in Table 1.