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Reliable B Cell Epitope Predictions: Impacts of Method Development and Improved Benchmarking

Figure 1

Cross-validated performance.

Performances of different methods for predicting B-cell epitopes evaluated on the DiscoTope dataset. From left to right: The original DiscoTope method, the uncombined log-odds ratio scores as described in text, the surface measures; UHS, RSA, FS HSE and Ta (see text) and the DiscoTope2.0 method as described in text. Performance of the original DiscoTope method was obtained from [12].

Figure 1

doi: https://doi.org/10.1371/journal.pcbi.1002829.g001