The Origin of Minus-end Directionality and Mechanochemistry of Ncd Motors
Figure 5
ATP dependent population change and minus-end directed power stroke of Ncd on MT track.
(a) Distributions of the angle (θ), among LEU296 in the unbound monomer and D424, E567 in the bound monomer, calculated from simulation for φ-ADP state on MT. The structure of Ncd with θ∼25° (peak position) is depicted on the MTs. (b) The angle (θ) distribution calculated from simulation for the ATP-ADP state. The structure of the Ncd on the MT with θ∼150° (peak position) is shown on the top. Change from φ-ADP to ATP-ADP state (a→b) implies the minus-end-directed power stroke.