Temporal Expression-based Analysis of Metabolism
Figure 3
Overall distribution of S. oneidensis gene expression measurements with two individual genes highlighted.
Distributions calculated using a pooled set of data from M3D [17] and time-course experimental data [18]. For both example genes, the distribution of gene expression measurements and the corresponding cumulative distribution function (CDF) are shown. For each CDF, individual gene penalty thresholds are found for common percentiles θ = 25%, 50% and 75%. D-lactate dehydrogenase expression measurements (A) have a higher mean expression and a more pronounced peak than acetate kinase (C), which is more uniformly distributed. The corresponding CDFs capture this variation in distribution. D-lactate dehydrogenase expression penalties (B) are higher and less distributed than those of acetate kinase (D). Mean gene expression (E) and standard deviation (F) over all genes for a single time point are also shown. All microarrays contain 4230 gene products, and each individual distribution contains 310 data points; 19 come from the experimental time-course and 281 from M3D.