Molecular Basis of Calcium-Sensitizing and Desensitizing Mutations of the Human Cardiac Troponin C Regulatory Domain: A Multi-Scale Simulation Study
Figure 4
Simulated NMR order parameters.
Order parameters are provided for apo (dashed) and holo (solid) for LOF mutants V79Q (blue), E40A (black) b) and GOF mutants V44Q (red), L48Q (green). Site I and site II are located at approximately residues 28–38 and 67–76, respectively. revN:19.