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Molecular Basis of Calcium-Sensitizing and Desensitizing Mutations of the Human Cardiac Troponin C Regulatory Domain: A Multi-Scale Simulation Study

Figure 2

Superposition of representative molecular dynamics snapshots for apo and holo mutant structures.

apo and holo states demonstrate the similar backbone structure for E40A (black) V44Q (red), L48Q (green), and V79Q (blue).

doi: https://doi.org/10.1371/journal.pcbi.1002777.g002