Molecular Basis of Calcium-Sensitizing and Desensitizing Mutations of the Human Cardiac Troponin C Regulatory Domain: A Multi-Scale Simulation Study

doi:10.1371/journal.pcbi.1002777

Molecular Basis of Calcium-Sensitizing and Desensitizing Mutations of the Human Cardiac Troponin C Regulatory Domain: A Multi-Scale Simulation Study

Figure 1

Structure of wild-type cardiac Troponin C.

The physiologically inactive binding site I contains (yellow), while the active site II region contains (tan). The locations of the mutants in this study are marked as colored bands, including E40 (black) V44 (red), L48 (green) and V79 (blue).

doi: https://doi.org/10.1371/journal.pcbi.1002777.g001