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A Graphical Modelling Approach to the Dissection of Highly Correlated Transcription Factor Binding Site Profiles

Figure 7

Combinatorial patterns of TFs in inferred causal neighbourhoods.

For each combinatorial pattern we show the number of CRMs with this pattern in the CRM class and that in the rest of CRMs (percentages are given in parenthesis). The difference in the two frequencies (CRM class vs rest) and the corresponding P-value are given in the last two columns. P-values were computed from Fisher's exact test for each combination and adjusted for multiple testing using the Benjamini-Hochberg method. See Materials and Methods for details. Frequency differences are colour-coded: blue for decrease in the CRM class, and orange for increase in the CRM class.

Figure 7

doi: https://doi.org/10.1371/journal.pcbi.1002725.g007