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Osteoprotegerin in Bone Metastases: Mathematical Solution to the Puzzle

Figure 7

PTHrP production by tumor.

A Starting from the initial conditions described in Figure 3, the PTHrP and RANKL concentrations, the osteoclast population density (OC) and the tumor density (Tumor) are shown at 45 and 90 days, respectively. The initial host–tissue level of RANKL is . For , tumor produces PTHrP at rates . Length of domain is , only the right halves of the symmetric fields are shown, the units of the y-axes are as in Figure 4, and PTHrP has units . B The simulations in A were repeated for the initial host tissue level of RANKL .

doi: https://doi.org/10.1371/journal.pcbi.1002703.g007