Osteoprotegerin in Bone Metastases: Mathematical Solution to the Puzzle
Figure 6
Direct RANKL production by tumor.
Starting from the initial conditions described in Figure 3, the RANKL concentration, the osteoclast population density (OC) and the tumor density (Tumor) are shown at 30 and 60 days, respectively. The initial host-tissue level of RANKL is . For
, RANKL is produced by the tumor at varying rates
. Length of domain is
, only the right halves of the symmetric fields are shown, the units of the y-axes are as in Figure 4.