Prediction and Dissection of Widely-Varying Association Rate Constants of Actin-Binding Proteins
Figure 2
Structures of seven ABPs complexed with G-actin.
(A) G-actin, with subdomains shown in magenta, green, yellow, and red, respectively. (B) Profilin. (C) Twinfilin ADF-homology domain 2. (D) Gelsolin domain 1. (E) WASP WH2, linker, and central segments. (F) Ciboulot domain 1. (G) Thymosin β4. (H) Vitamin-D binding protein. The cleft-lying helices of all seven ABPs are shown in yellow. The C-terminal portions of the ABPs in (E) and (F), shown in light color, are modeled and can easily dissociate. In (H) the three domains of DBP are in dark blue, cyan, and light blue respectively.