Tissue-Specific Functional Networks for Prioritizing Phenotype and Disease Genes
Figure 6
Top connected genes to Atcay in the cerebellum-specific network reveals likely ataxia candidates.
Edges with weight greater than 0.9 are shown. In the cerebellum network (A), Grm1 and Cacn1a are the top predicted connections to Atcay, with confidences of 0.902 and 0.943, respectively. Both genes are closely connected to Atcay and its top 10 neighbors. In the global network (B), Grm1 and Cacn1a are much more weakly connected to Atcay (0.763 and 0.647, respectively), and are not identified as top connectors to Atcay. Grm1 and Cacn1a are not connected to Atcay or any of its top 10 neighbors in the global network.