Tissue-Specific Functional Networks for Prioritizing Phenotype and Disease Genes
Figure 2
Tissue-specific networks are more accurate than the global network in reflecting protein functional relationships.
A. 107 tissues were grouped into major body systems according to the anatomical hierarchical structure maintained in GXD [20]. Through three-fold cross-validation, the performance of tissue-specific networks was compared against the global network and the percentage improvement of tissue-specific networks over the global network was plotted. All tissue-specific networks out-performed the global network in this cross-validation analysis. Improvements were consistent across tissues belonging to all major organ systems. Candle-stick plots (minimum, 25%, median, 75% and maximum) represent the distribution of percentage AUC improvement for all tissues in a specific system. B. Example precision recall curves of tissue-specific and the global network, generated using three-fold cross-validation. Across the entire precision-recall space, tissue-specific networks performed better than the global network. Complete precision-recall figures for all networks are included in Dataset S2.