Determinants of Brain Cell Metabolic Phenotypes and Energy Substrate Utilization Unraveled with a Modeling Approach
Figure 3
Importance of lactate transport for oxidative phosphorylation in oxidative cells.
(A) As a starting point, it was assumed that lactate transport and glycolysis contribute 43% and 57%, respectively, to oxidative phosphorylation (r = 0.75 [29]). Lactate transport was then stimulated by increasing vmax,MCT and Le in the range 0–80%. The iso-curves show JPDH normalized to its basal value (as a measure of oxidative phosphorylation). Note that in parallel, vmax,PDH and kshuttle were multiplied by a factor f = 1.3, while the glycolytic flux remained fixed to its basal level. In all regions, the ratio [32] and
[34]. (B) As in (A), but f = 1.7. (C) As in (A), but r = 2.2 [28]. (D) As in (A), but r = 2.2 [28] and f = 1.7. See Description of the model for equations and Choice of parameters for parameters.