Stress-Induced Impairment of a Working Memory Task: Role of Spiking Rate and Spiking History Predicted Discharge
Figure 4
Stress-related changes in plPFC neuron spike-history predicted discharge (SHPD) throughout baseline or acute stress conditions.
A) Spiking gain (rate-ratio expα,η) measures of the contribution of spike history at different points back in time for a small (n = 50) ensemble of neurons. The SHPD gain of one exemplar neuron is highlighted. B) SHPD gain at different points back in time decay exponentially under baseline and stress conditions (Model 1a). Described in the main text, stress produced an overall reduction in SHPD gains (inset; *p<0.005), but did not significantly alter the decay of gains at any spike history time bin. C) Schematic of recurrent pathways within the PFC of connectivity within layers II/III or V as well as connectivity between II/III and V represents one putative mechanism supporting SHPD. Adopted from: [72]–[74].