Quantitative Predictions of Binding Free Energy Changes in Drug-Resistant Influenza Neuraminidase
Figure 4
Differences in hydrogen bonding with the zanamivir tail in the H274Y mutant.
Distribution of the average distance between the atoms Oε of E276 and E277 with O21 and O23 in the trihydroxypropyl group of zanamivir in wild type (A) and in the H274Y mutant (B).