Spontaneous Excitation Patterns Computed for Axons with Injury-like Impairments of Sodium Channels and Na/K Pumps
Figure 6
Classes of Nav-CLS-induced activities with two injured and one intact gNa population.
(A) Membrane excitability map of injured node with LSi = [26.5,2,0]mV. White, pink, green and blue regions represent different stable state activities: quiescence, bursts, tonic firing, and bistability between quiescence and tonic firing. Here the fraction of intact gNa is f3 = 1−f1−f2. (B) and (C), typical Vm trajectories when the system is in bursting and bistability regimes, respectively.