Spontaneous Excitation Patterns Computed for Axons with Injury-like Impairments of Sodium Channels and Na/K Pumps
Figure 3
Ectopic steady-state Vm excursions are tuned by Ipump.
(A) From the spontaneous tonic firing regime of Figure 9 in [11], a random point (LSi = [0,15]mV, fi = [0.5,0.5]) is selected; as illustrated, Vm oscillation amplitude varies as Imaxpump is set at 30 and 95 µA/cm2. (B) Ipump changes from a constant 10 µA/cm2 (associated with a small periodic Vm fluctuation) to a fluctuating 23±0.5 µA/cm2 (associated with a train of APs). (C) Corresponding total INa. (D) With growing Imaxpump, voltage excursions (blue) increase and their oscillation frequencies (red) decrease.