Hybrid Models and Biological Model Reduction with PyDSTool

doi:10.1371/journal.pcbi.1002628

Hybrid Models and Biological Model Reduction with PyDSTool

Figure 1

Class containment diagram for a hybrid model in PyDSTool.

represent ‘internal’ model interface objects that wrap sub-models (). If global consistency conditions are applied to these sub-models, then ‘external’ model interface objects, , may also be provided. Each iMI may either contain a non-hybrid or another hybrid model object (an example is shown). Non-hybrid models combine with a GeneratorInterface to make a thin wrapper for Generator objects, ensuring API-compatibility with hybrid model objects and other MIs and thus promoting interchangeability. Conditions in each eMI specify a target combination of truth or falsity of one or more constituent features. The features measure properties of the corresponding iMI and compare them to those in some external data such as a user-imposed logical template or experimental data.

doi: https://doi.org/10.1371/journal.pcbi.1002628.g001