Single Nucleotide Polymorphisms Can Create Alternative Polyadenylation Signals and Affect Gene Expression through Loss of MicroRNA-Regulation
Figure 5
SNP expression difference between SNPs with positive and negative log allelic ratios.
Logarithm of SNP expression median difference between SNPs with positive log allelic ratios and those with negative log allelic ratios, in several groups (low and high GU level, low (LMS) and high (HMS) miRNA score, and weak (W) and strong (S) signal). Crosses show median differences. Bootstrapping median differences gives 95% CI. Only one CI does not contain zero: the one with high GU, HMS and S, indicating that positive allelic imbalance for SNPs in strong polyA sites and affecting miRNA target sites, is associated with increased SNP expression, and therefore increased gene expression.