Single Nucleotide Polymorphisms Can Create Alternative Polyadenylation Signals and Affect Gene Expression through Loss of MicroRNA-Regulation
Figure 3
Increased allelic imbalance correlates with signal strength and depends on downstream GU-content.
Log allelic ratio distribution of APA allele over non-APA allele for each polyA signal ordered by strength. Panel (A): log allelic ratio is negatively correlated with signal rank for all APA-SNPs. Compared with all APA-SNPs, APA-SNPs with a GU-rich region (Panel (B)) have a stronger negative correlation between log allelic ratio and signal rank. For APA-SNPs without a GU-rich region (Panel (C)), there is no significant correlation between signal rank and log allelic ratio. The graphs include data from the 19 non-mixed cell lines and tissues. The line in each panel shows the linear regression line; the corresponding Pearson correlation coefficient is in the panel's upper left corner.