Combining the Finite Element Method with Structural Connectome-based Analysis for Modeling Neurotrauma: Connectome Neurotrauma Mechanics
Figure 4
Evolution of damaged tracts and the corresponding structural networks.
Using empirically-based cellular death predictions obtained from in vitro models of neural tissues, local strain and strain rate values computed from finite element simulations are used to specify injury. A computed cellular death of 3% was used as a critical value for defining white matter disruption. Damage is shown in red and the node size represents the percent change of degree. The predicted evolution of damage is shown for the sagittal and corresponding transverse views for 24 (a and b), 48 (c and d), 72 (e and f), and 96 hours (g and h).