Genome-Wide Localization of Protein-DNA Binding and Histone Modification by a Bayesian Change-Point Method with ChIP-seq Data
Figure 4
BCP dynamically adapted to many different types of data.
To demonstrate its versatility, we compiled a set of several histone modifications and analyzed each under the default parameters for BCP and SICER. Regardless of the histone mark characteristics, whether more punctate as in acetylation marks and H3K4me3 or broad as in H3K27me3, H3K36me3, and H3K9me3, BCP (black) was able to make reasonable island calls that effectively described the underlying read profiles. SICER (grey) seemed more primed to identify smaller, sharper islands so often fragmented more general regions of enrichment.