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Modeling of Pharmacokinetics of Cocaine in Human Reveals the Feasibility for Development of Enzyme Therapies for Drugs of Abuse

Table 2

The maximum cocaine plasma concentration, i.e. the value (µM), which a given concentration ([E] = 0.035 or 0.5 µM) of cocaine-metabolizing enzyme (CocE, CocH1, CocH2, or CocH3) can effectively prevent from entering brain and producing physiological effects.

doi: https://doi.org/10.1371/journal.pcbi.1002610.t002