Modeling of Pharmacokinetics of Cocaine in Human Reveals the Feasibility for Development of Enzyme Therapies for Drugs of Abuse
Figure 4
Comparison between the (+)-cocaine hydrolysis by wide-type BChE and the (−)-cocaine hydrolysis by CocH3.
Upper panel: modeled (−)-cocaine concentration in the brain of human subject with the presence of wild-type BChE or CocH3 in plasma. Lower panel: reported (−)- and (+)-cocaine concentrations in baboon brain (striatum) with the presence of wild-type BChE in plasma; the data from reference [62].