Location-Dependent Excitatory Synaptic Interactions in Pyramidal Neuron Dendrites
Figure 4
Proximal-distal interactions in a time-invariant 2-compartmental model are nearly indistinguishable from those produced by the detailed compartmental model.
A, Schematic proximal and distal ‘stimulating electrodes’ are shown activating one highlighted terminal basal dendrite. B, Peak somatic responses for inputs at 90 and 150 µm as illustrated in (A). Plot shares color bar with Figure 3A. C, 2-compartment circuit diagram with proximal and distal NMDA conductances. D, Time-invariant responses for 2-compartment model. Parameters were hand tuned to resemble (C): Axial, distal leak and proximal leak conductances were 2.5,0.25, and 4 A.U., respectively. NMDA peak conductance was 0.5 A.U. per synapse. Overall peak response in 2-compartment model was scaled to match overall peak in (C) (Vsoma = 15.2 mV). For details on 2-compartment model see Figure S1 in Text S1.