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Modular Design of Artificial Tissue Homeostasis: Robust Control through Synthetic Cellular Heterogeneity

Figure 2

System 1.

(A) Circuit diagram: two Population Control modules (in gray) sense the density of stem- and -cells. The AND gate integrates the output of the modules to induce differentiation. Circles represent intercellular signaling molecules. (B) Two examples of population evolution showing sustained oscillations (point 1 in C) and a stable steady state (point 2 in C), with other parameters fixed (SI Sec. 2 and Figure S2). (C) A planar slice of the parameter space where population oscillations occur for System 1.

Figure 2

doi: https://doi.org/10.1371/journal.pcbi.1002579.g002