Prediction of Microbial Growth Rate versus Biomass Yield by a Metabolic Network with Kinetic Parameters
Figure 1
Enzyme turnover numbers and enzyme molecular weights are significantly correlated with metabolic flux rates.
(A) Correlations of enzyme turnover numbers, enzyme molecular weights, gene expression levels, and combinations of the latter via a linear regression model with measured metabolic flux rates. Measured flux rates in E.coli under glucose minimal media in low and high growth rates were taken from Ishii et al. [17], and Schuetz et al. data [18], respectively. Each bar represents a correlation between flux rates and a single or multiple data sources (marked by ‘+’ signs). (B) Enzyme turnover numbers correlate with measured metabolic flux rates in E. coli (both in log10 scale). Linear regression line in red.